MFAP1

Across TCGA pan-cancer cohorts, MFAP1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MFAP1 data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MFAP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MFAP1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where MFAP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.523	0.852	.007	19	view →
LSCC	DFS	Tertile	II,III,IV	0.888	0.550	.020	12	view →
CCRCC	DFS	Quartile	All	0.894	1.000	.030	6	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	3	view →
UCEC	DFS	Tertile	All	0.946	0.789	.042	2	view →
PDAC	DFS	Median	All	0.424	0.278	.047	2	view →
GBM	OS	Tertile	All	0.469	0.257	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MFAP1–HNSC (DFS)

Open the HNSC breakdown →