MEX3D

Across TCGA pan-cancer cohorts, MEX3D mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MEX3D data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MEX3D mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MEX3D expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where MEX3D mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.692	0.881	.009	17	view →
LUAD	OS	Median	II,III,IV	0.795	0.452	.029	6	view →
PDAC	DFS	Median	II,III,IV	0.304	0.619	.025	4	view →
GBM	OS	Median	All	0.561	0.269	.042	1	view →
LSCC	OS	Tertile	All	0.931	0.754	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MEX3D–HNSC (DFS)

Open the HNSC breakdown →