MEX3A

Across TCGA patient cohorts, MEX3A mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEX3A-associated genes across cancer lineages are Src_pY527, INPP4B, and JNK2. Each is linked with MEX3A in more than 1 cancer types. Because this analysis shows association rather than direction, both MEX3A-to-partner and partner-to-MEX3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY527 grouped by MEX3A-low versus MEX3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEX3A→partner) and Y-score (partner→MEX3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Src_pY527 →	-0.488	-3.311	.011	.010	3	2
UCEC	INPP4B →	-0.317	-2.999	.029	.035	3	1
UCEC	JNK2 →	+0.235	+2.000	.008	.032	3	1
UCEC	MAPK_pT202_Y204 →	-0.508	-3.459	.016	.005	3	1
UCEC	PCNA →	+0.288	+3.169	.003	.018	3	1
UCEC	PDCD4 →	-0.570	-2.999	.007	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Src_pY527 by MEX3A expression — UCEC

Explore this box plot interactively →