Across TCGA patient cohorts, METTL9 mutation is significantly associated with the RNA expression of many other genes, with 501 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL9-associated genes across cancer lineages are SNORD114-12, RNA5SP76, and RNU6-352P. Each is linked with METTL9 in more than 2 cancer types. Because this analysis shows association rather than direction, both METTL9-to-partner and partner-to-METTL9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL9→partner) and Y-score (partner→METTL9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	SNORD114-12 →	+0.734	+4.536	<.001	.001	3	3
BRCA	RNA5SP76 →	+1.446	+7.731	<.001	.009	3	2
BRCA	RNU6-352P →	+1.757	+7.731	<.001	.009	3	2
BRCA	RNU6-148P →	+0.657	+7.731	<.001	.009	3	2
UCEC	RNA5SP411 →	+1.615	+3.393	<.001	<.001	3	2
LUAD	RNA5SP432 →	+0.721	+5.888	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 501 associations by consensus.

Exploration

METTL9 survival (RNA) · tumor vs normal (RNA) · all METTL9 data types