Across TCGA patient cohorts, METTL9 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL9-associated genes across cancer lineages are mTOR_pS2448, PDCD4, and Shc_pY317. Each is linked with METTL9 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL9-to-partner and partner-to-METTL9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL9→partner) and Y-score (partner→METTL9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.199	-2.980	.011	.036	3	1
UCEC	PDCD4 →	-0.795	-3.321	.001	.010	3	1
UCEC	Shc_pY317 →	-0.161	-3.321	.043	.010	3	1
UCEC	TIGAR →	+0.201	+3.348	.012	.005	3	1
UCEC	Bax →	+0.398	+3.321	.001	.010	3	1
UCEC	p62 Lck ligand →	+0.695	+2.179	<.001	.034	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

METTL9 survival (RNA) · tumor vs normal (RNA) · all METTL9 data types