Across TCGA cell cohorts, METTL9 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible METTL9-associated genes across cancer lineages are ZNF831, CDX4, and SCT. Each is linked with METTL9 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL9-to-partner and partner-to-METTL9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL9→partner) and Y-score (partner→METTL9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF831 →	+0.018	+4.273	<.001	.006	3	1
LARGE_INTESTINE	CDX4 →	+0.019	+5.217	<.001	<.001	3	1
LARGE_INTESTINE	SCT →	+0.243	+4.095	<.001	.009	3	1
SKIN	KRTAP4-11 →	+0.019	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

METTL9 survival (RNA) · tumor vs normal (RNA) · all METTL9 data types