METTL8P1

Across TCGA pan-cancer cohorts, METTL8P1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of METTL8P1’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where METTL8P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types METTL8P1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

BRCA, LUSC, and THCA are the cancer types where METTL8P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in METTL8P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	II,III,IV	+0.146	.019	4	view →
LUSC	All	All	+0.128	.001	4	view →
THCA	All	All	−0.036	.008	3	view →
READ	Male	All	+0.233	.016	2	view →
LUAD	All	IV	+0.205	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

METTL8P1–BRCA

Open the BRCA breakdown →