METTL8

Across TCGA patient cohorts, METTL8 protein abundance is significantly associated with the protein abundance of many other proteins, with 16,970 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible METTL8-associated proteins across cancer lineages are DAP3, CLPX, and KEAP1. Each is linked with METTL8 in more than 4 cancer types. Because this analysis shows association rather than direction, both METTL8-to-partner and partner-to-METTL8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, METTL8 versus DAP3 in LSCC, with a Pearson correlation of 0.70.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL8→partner) and Y-score (partner→METTL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DAP3 →	+0.525	+0.655	<.001	<.001	3	5
BRCA	CLPX →	+0.385	+0.710	<.001	<.001	3	5
LSCC	KEAP1 →	+0.571	+0.614	<.001	<.001	3	4
LSCC	METAP1 →	+0.245	+0.563	<.001	<.001	3	4
LSCC	TFB1M →	+0.587	+0.589	<.001	<.001	3	4
LSCC	TFB2M →	+0.441	+0.595	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,970 associations by consensus.

METTL8 vs DAP3 — LSCC

Explore this scatter interactively →