METTL8

Across TCGA patient cohorts, METTL8 mutation is significantly associated with the RNA expression of many other genes, with 256 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL8-associated genes across cancer lineages are RNA5SP213, RNA5SP410, and RPL7AP69. Each is linked with METTL8 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL8-to-partner and partner-to-METTL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP213 grouped by METTL8-low versus METTL8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL8→partner) and Y-score (partner→METTL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP213 →	+0.522	+3.008	<.001	.007	3	2
UCEC	RNA5SP410 →	+0.596	+2.052	<.001	.009	3	2
SKCM	RPL7AP69 →	+0.053	+4.034	<.001	.004	3	1
CESC	IGHD5-24 →	+1.340	+4.669	<.001	.007	3	1
CESC	RNU6-269P →	+0.299	+4.539	<.001	.008	3	1
CESC	ALDH7A1P2 →	+0.087	+4.539	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 256 associations by consensus.

RNA5SP213 by METTL8 expression — UCEC

Explore this box plot interactively →