METTL8

Across TCGA patient cohorts, METTL8 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL8-associated genes across cancer lineages are JNK_pT183_Y185, Mre11, and PREX1. Each is linked with METTL8 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL8-to-partner and partner-to-METTL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by METTL8-low versus METTL8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL8→partner) and Y-score (partner→METTL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.174	-1.986	.021	.032	3	1
UCEC	Mre11 →	-0.106	-2.973	.006	.035	3	1
UCEC	PREX1 →	-0.268	-2.999	.030	.035	3	1
UCEC	Shc_pY317 →	-0.194	-2.000	.004	.032	3	1
UCEC	STAT3_pY705 →	-0.345	-3.169	.003	.018	3	1
UCEC	4E-BP1 →	+0.335	+2.700	.006	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

JNK_pT183_Y185 by METTL8 expression — UCEC

Explore this box plot interactively →