METTL8

Across TCGA cell cohorts, METTL8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,576 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible METTL8-associated GO terms across cancer lineages are tRNA C3-cytosine methylation, Mitochondrial tRNA processing, and Mitochondrial RNA modification. Each is linked with METTL8 in more than 19 cancer types. Because this analysis shows association rather than direction, both METTL8-to-partner and partner-to-METTL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, tRNA C3-cytosine methylation grouped by METTL8-low versus METTL8-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL8→partner) and Y-score (partner→METTL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	tRNA C3-cytosine methylation →	+0.174	+1.186	<.001	<.001	3	20
BONE	Mitochondrial tRNA processing →	+0.111	+0.684	<.001	<.001	3	19
BONE	Mitochondrial RNA modification →	+0.154	+0.914	<.001	<.001	3	19
URINARY_TRACT	Mitochondrial tRNA modification →	+0.145	+1.017	<.001	<.001	3	19
LARGE_INTESTINE	Positive regulation of mitochondrial translation →	+0.125	+1.062	<.001	<.001	3	18
BONE	Mitochondrial RNA processing →	+0.133	+0.705	<.001	<.001	2	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,576 associations by consensus.

tRNA C3-cytosine methylation by METTL8 expression — KIDNEY

Explore this box plot interactively →