METTL8

Across TCGA cell cohorts, METTL8 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible METTL8-associated genes across cancer lineages are MMP27, KRTAP12-3, and DCD. Each is linked with METTL8 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL8-to-partner and partner-to-METTL8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP27 grouped by METTL8-low versus METTL8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL8→partner) and Y-score (partner→METTL8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MMP27 →	+0.026	+5.969	<.001	.001	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.082	+5.539	<.001	.003	3	1
SKIN	DCD →	+0.068	+4.977	.001	.007	3	1
SKIN	RLN3 →	+0.063	+4.977	<.001	.007	3	1
SKIN	OPN1MW →	+0.036	+5.415	<.001	.004	3	1
LUNG_NSCLC_LUAD	AKAP4 →	+0.013	+4.544	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

MMP27 by METTL8 expression — BLOOD_Leukemia

Explore this box plot interactively →