Across TCGA patient cohorts, METTL6 protein abundance is significantly associated with the RNA expression of many other genes, with 1,511 significant associations in total. GBM shows the largest number of these associations.

The most reproducible METTL6-associated genes across cancer lineages are NDUFA10, FAM185BP, and PHKB. Each is linked with METTL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL6-to-partner and partner-to-METTL6 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL6→partner) and Y-score (partner→METTL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NDUFA10 →	-0.468	-0.410	<.001	.001	3	2
BRCA	FAM185BP →	-0.628	-0.492	.003	.008	3	2
GBM	PHKB →	-0.456	-0.420	.007	<.001	3	2
LUAD	GAPDHP52 →	-0.697	-0.604	.001	.006	3	2
BRCA	ZNF574 →	-0.556	-0.377	.009	.004	3	1
BRCA	NPR3 →	+1.334	+0.498	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,511 associations by consensus.

Exploration

METTL6 survival (RNA) · tumor vs normal (RNA) · all METTL6 data types