Across TCGA patient cohorts, METTL6 mutation is significantly associated with the RNA expression of many other genes, with 1,055 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL6-associated genes across cancer lineages are TOMM22P5, IMMP1L, and INTS4. Each is linked with METTL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL6-to-partner and partner-to-METTL6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL6→partner) and Y-score (partner→METTL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TOMM22P5 →	+0.215	+3.160	.003	<.001	3	2
UCEC	IMMP1L →	+0.534	+2.595	.001	.006	3	1
UCEC	INTS4 →	+0.395	+3.332	.005	.005	3	1
UCEC	LAS1L →	+0.379	+3.202	.006	.009	3	1
UCEC	TEX30 →	+0.815	+3.467	<.001	.002	3	1
UCEC	NDUFC2 →	+0.764	+3.700	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,055 associations by consensus.

Exploration

METTL6 survival (RNA) · tumor vs normal (RNA) · all METTL6 data types