Across TCGA patient cohorts, METTL6 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL6-associated genes across cancer lineages are JNK2, LKB1, and MEK1. Each is linked with METTL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL6-to-partner and partner-to-METTL6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL6→partner) and Y-score (partner→METTL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.311	+3.026	.004	.018	3	1
UCEC	LKB1 →	-0.123	-3.169	.034	.020	3	1
UCEC	MEK1 →	+0.477	+3.169	.017	.020	3	1
UCEC	Notch1 →	+0.226	+2.820	.003	.035	3	1
UCEC	p27_pT157 →	-0.065	-3.169	.042	.020	3	1
UCEC	Cyclin-E2 →	+0.198	+2.817	.032	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

METTL6 survival (RNA) · tumor vs normal (RNA) · all METTL6 data types