Across TCGA cell cohorts, METTL6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,608 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible METTL6-associated GO terms across cancer lineages are tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation, tRNA C3-cytosine methylation, and tRNA 3'-terminal CCA addition. Each is linked with METTL6 in more than 15 cancer types. Because this analysis shows association rather than direction, both METTL6-to-partner and partner-to-METTL6 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL6→partner) and Y-score (partner→METTL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation →	+0.181	+1.041	<.001	<.001	3	16
OESOPHAGUS	tRNA C3-cytosine methylation →	+0.188	+1.117	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	tRNA 3'-terminal CCA addition →	+0.126	+1.017	<.001	<.001	3	14
LUNG_NSCLC_LUAD	Transcription elongation by RNA polymerase II →	+0.062	+0.486	<.001	.001	3	14
UPPER_AERODIGESTIVE_TRACT	Protein localization to non-motile cilium →	+0.072	+1.019	.001	.003	3	14
OESOPHAGUS	Protein histidyl modification to diphthamide →	+0.143	+1.120	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,608 associations by consensus.

Exploration

METTL6 survival (RNA) · tumor vs normal (RNA) · all METTL6 data types