METTL5

Across TCGA patient cohorts, METTL5 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,994 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible METTL5-associated proteins across cancer lineages are SSB, RIF1, and HAT1. Each is linked with METTL5 in more than 6 cancer types. Because this analysis shows association rather than direction, both METTL5-to-partner and partner-to-METTL5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, METTL5 versus SSB in LSCC, with a Pearson correlation of 0.74.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL5→partner) and Y-score (partner→METTL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SSB →	+0.424	+0.660	<.001	<.001	3	7
LSCC	RIF1 →	+0.454	+0.547	<.001	<.001	3	6
LSCC	HAT1 →	+0.401	+0.384	<.001	<.001	3	5
LUAD	RRM2 →	+0.640	+0.304	<.001	<.001	3	5
LUAD	MCM2 →	+0.537	+0.276	<.001	.003	3	5
LUAD	MCM4 →	+0.613	+0.338	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,994 associations by consensus.

METTL5 vs SSB — LSCC

Explore this scatter interactively →