METTL5

Across TCGA patient cohorts, METTL5 protein abundance is significantly associated with the RNA expression of many other genes, with 7,027 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible METTL5-associated genes across cancer lineages are PSMD14, OLA1, and SSB. Each is linked with METTL5 in more than 4 cancer types. Because this analysis shows association rather than direction, both METTL5-to-partner and partner-to-METTL5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, METTL5 versus PSMD14 in LSCC, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL5→partner) and Y-score (partner→METTL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PSMD14 →	+0.572	+0.332	<.001	<.001	3	5
OV	OLA1 →	+0.569	+0.374	<.001	<.001	3	5
UCEC	SSB →	+0.577	+0.281	.002	<.001	3	4
OV	FASTKD1 →	+0.551	+0.352	<.001	.002	3	4
LSCC	PDSS1 →	+0.571	+0.267	<.001	<.001	3	4
LSCC	TCOF1 →	+0.578	+0.317	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,027 associations by consensus.

METTL5 vs PSMD14 — LSCC

Explore this scatter interactively →