METTL5

Across TCGA patient cohorts, METTL5 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL5-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and JNK_pT183_Y185. Each is linked with METTL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL5-to-partner and partner-to-METTL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by METTL5-low versus METTL5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL5→partner) and Y-score (partner→METTL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.293	-3.169	.009	.018	3	1
UCEC	A-Raf_pS299 →	-0.164	-3.169	.002	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.215	-3.459	.004	.005	3	1
UCEC	MEK1 →	+0.424	+2.584	.010	.010	3	1
UCEC	mTOR_pS2448 →	-0.177	-3.439	.008	.005	3	1
UCEC	Notch1 →	+0.191	+2.000	.002	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

EGFR_pY1068 by METTL5 expression — UCEC

Explore this box plot interactively →