METTL5

Across TCGA cell cohorts, METTL5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,555 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible METTL5-associated GO terms across cancer lineages are Protein insertion into mitochondrial inner membrane from matrix, tRNA C3-cytosine methylation, and Mitochondrial RNA processing. Each is linked with METTL5 in more than 14 cancer types. Because this analysis shows association rather than direction, both METTL5-to-partner and partner-to-METTL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein insertion into mitochondrial inner membrane from matrix grouped by METTL5-low versus METTL5-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL5→partner) and Y-score (partner→METTL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Protein insertion into mitochondrial inner membrane from matrix →	+0.126	+0.742	.002	.004	2	15
LIVER	tRNA C3-cytosine methylation →	+0.189	+0.758	<.001	<.001	3	10
BREAST	Mitochondrial RNA processing →	+0.078	+0.663	<.001	<.001	3	10
BLOOD_Myeloma	Positive regulation of mitochondrial ATP synthesis coupled electron transport →	+0.153	+0.487	<.001	<.001	3	9
SKIN	Medulla oblongata development →	+0.130	+0.433	.002	.003	3	9
SKIN	Regulation of cardiolipin metabolic process →	+0.139	+0.392	<.001	.009	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,555 associations by consensus.

Protein insertion into mitochondrial inner membrane from matrix by METTL5 expression — STOMACH

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