METTL3

Across TCGA patient cohorts, METTL3 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL3-associated genes across cancer lineages are RBM15, 14-3-3_beta, and GATA6. Each is linked with METTL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL3-to-partner and partner-to-METTL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBM15 grouped by METTL3-low versus METTL3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL3→partner) and Y-score (partner→METTL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RBM15 →	+0.475	+2.321	.013	.032	3	1
UCEC	14-3-3_beta →	-0.157	-3.295	.001	.009	3	1
UCEC	GATA6 →	-0.194	-2.459	.009	.019	3	1
UCEC	JNK2 →	+0.280	+2.817	.003	.036	3	1
UCEC	N-Ras →	-0.115	-2.446	.046	.020	3	1
UCEC	p62 Lck ligand →	+0.365	+3.009	.020	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

RBM15 by METTL3 expression — BLCA

Explore this box plot interactively →