METTL3

Across TCGA cell cohorts, METTL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,898 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible METTL3-associated GO terms across cancer lineages are Endothelial to hematopoietic transition, DNA replication checkpoint signaling, and Microtubule nucleation. Each is linked with METTL3 in more than 18 cancer types. Because this analysis shows association rather than direction, both METTL3-to-partner and partner-to-METTL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endothelial to hematopoietic transition grouped by METTL3-low versus METTL3-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL3→partner) and Y-score (partner→METTL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Endothelial to hematopoietic transition →	+0.149	+1.158	<.001	<.001	3	19
BONE	DNA replication checkpoint signaling →	+0.233	+0.801	<.001	.002	3	17
OESOPHAGUS	Microtubule nucleation →	+0.119	+1.423	<.001	.001	3	17
SOFT_TISSUE	Replication fork processing →	+0.139	+1.091	<.001	<.001	3	16
SOFT_TISSUE	DNA-templated DNA replication maintenance of fidelity →	+0.136	+1.020	<.001	<.001	3	16
URINARY_TRACT	Microtubule polymerization →	+0.112	+0.888	.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,898 associations by consensus.

Endothelial to hematopoietic transition by METTL3 expression — SOFT_TISSUE

Explore this box plot interactively →