METTL2B

Across TCGA patient cohorts, METTL2B mutation is significantly associated with the RNA expression of many other genes, with 751 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL2B-associated genes across cancer lineages are MRPL50P4, RNU6-389P, and SEPTIN7P4. Each is linked with METTL2B in more than 2 cancer types. Because this analysis shows association rather than direction, both METTL2B-to-partner and partner-to-METTL2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL50P4 grouped by METTL2B-low versus METTL2B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL2B→partner) and Y-score (partner→METTL2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MRPL50P4 →	+0.073	+4.513	<.001	.009	3	3
BRCA	RNU6-389P →	+0.436	+6.324	<.001	.001	3	2
SKCM	SEPTIN7P4 →	+0.118	+4.970	<.001	.005	3	2
SKCM	RPL39P31 →	+0.210	+4.680	<.001	.007	3	2
SKCM	ANKRD33B-AS1 →	+0.110	+5.877	<.001	<.001	3	2
COAD	RNY3P14 →	+0.918	+5.145	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 751 associations by consensus.

MRPL50P4 by METTL2B expression — SKCM

Explore this box plot interactively →