METTL2B

Across TCGA patient cohorts, METTL2B mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL2B-associated genes across cancer lineages are EGFR_pY1068, FOXO3a_pS318_S321, and GSK-3_pS9. Each is linked with METTL2B in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL2B-to-partner and partner-to-METTL2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by METTL2B-low versus METTL2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL2B→partner) and Y-score (partner→METTL2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.272	-3.459	.008	.005	3	1
UCEC	FOXO3a_pS318_S321 →	-0.103	-1.690	.046	.042	3	1
UCEC	GSK-3_pS9 →	-0.452	-3.321	.006	.009	3	1
UCEC	MEK1 →	+0.356	+2.000	.018	.030	3	1
UCEC	NDRG1_pT346 →	-0.505	-3.321	.012	.009	3	1
UCEC	Notch1 →	+0.155	+1.807	.007	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

EGFR_pY1068 by METTL2B expression — UCEC

Explore this box plot interactively →