METTL2B

Across TCGA cell cohorts, METTL2B RNA expression is significantly associated with the go_rna of many other GO terms, with 3,618 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible METTL2B-associated GO terms across cancer lineages are Positive regulation of isotype switching to IgG isotypes, DNA-templated transcription termination, and Peptidyl-glutamic acid carboxylation. Each is linked with METTL2B in more than 15 cancer types. Because this analysis shows association rather than direction, both METTL2B-to-partner and partner-to-METTL2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of isotype switching to IgG isotypes grouped by METTL2B-low versus METTL2B-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL2B→partner) and Y-score (partner→METTL2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of isotype switching to IgG isotypes →	+0.160	+0.821	.005	.006	3	16
SOFT_TISSUE	DNA-templated transcription termination →	+0.110	+0.718	<.001	<.001	3	14
OESOPHAGUS	Peptidyl-glutamic acid carboxylation →	+0.142	+0.739	<.001	.008	3	14
OESOPHAGUS	Protein carboxylation →	+0.142	+0.739	<.001	.008	3	14
UPPER_AERODIGESTIVE_TRACT	tRNA processing →	+0.063	+0.893	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.114	+0.601	.004	.004	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,618 associations by consensus.

Positive regulation of isotype switching to IgG isotypes by METTL2B expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →