METTL27

Across TCGA pan-cancer cohorts, METTL27 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated METTL27 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher METTL27 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated METTL27 expression acts as an unfavorable survival marker.

BRCA, HNSC, and COAD are the cancer types where METTL27 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.561	0.924	<.001	24	view →
HNSC	DFS	Median	III,IV	0.122	0.680	.004	21	view →
COAD	DFS	Median	All	0.148	0.703	<.001	17	view →
LIHC	DFS	Median	All	0.044	0.553	<.001	12	view →
ESCA	OS	Median	All	0.147	0.700	.002	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	OS	Median	IV	0.247	0.752	.004	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

METTL27–BRCA (OS)

Open the BRCA breakdown →