METTL27

Across TCGA patient cohorts, METTL27 mutation is significantly associated with the RNA expression of many other genes, with 409 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL27-associated genes across cancer lineages are TRGJP2, SYT14P1, and TRAJ38. Each is linked with METTL27 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL27-to-partner and partner-to-METTL27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRGJP2 grouped by METTL27-low versus METTL27-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL27→partner) and Y-score (partner→METTL27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRGJP2 →	+1.277	+3.489	<.001	.005	3	2
COAD	SYT14P1 →	+0.044	+4.392	<.001	.006	3	2
UCEC	TRAJ38 →	+0.443	+2.174	<.001	.005	3	2
SKCM	RN7SKP286 →	+0.085	+5.810	<.001	<.001	3	2
SKCM	AP1B1P2 →	+0.185	+4.328	<.001	.007	3	2
BRCA	ELOA3CP →	+0.024	+7.731	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 409 associations by consensus.

TRGJP2 by METTL27 expression — COAD

Explore this box plot interactively →