METTL27

Across TCGA patient cohorts, METTL27 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL27-associated genes across cancer lineages are eIF4E, 14-3-3_beta, and Fibronectin. Each is linked with METTL27 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL27-to-partner and partner-to-METTL27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by METTL27-low versus METTL27-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL27→partner) and Y-score (partner→METTL27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.217	+3.169	.032	.019	3	2
UCEC	14-3-3_beta →	-0.130	-2.973	.007	.035	3	1
UCEC	Fibronectin →	-0.414	-3.449	.009	.005	3	1
UCEC	Ku80 →	+0.239	+2.472	.036	.011	3	1
UCEC	p62 Lck ligand →	+0.540	+3.584	<.001	.002	3	1
UCEC	PDK1_pS241 →	+0.270	+3.459	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

eIF4E by METTL27 expression — UCEC

Explore this box plot interactively →