METTL27

Across TCGA cell cohorts, METTL27 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,379 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible METTL27-associated GO terms across cancer lineages are Electron transport chain, Respiratory electron transport chain, and Aerobic electron transport chain. Each is linked with METTL27 in more than 8 cancer types. Because this analysis shows association rather than direction, both METTL27-to-partner and partner-to-METTL27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Electron transport chain grouped by METTL27-low versus METTL27-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL27→partner) and Y-score (partner→METTL27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Electron transport chain →	+0.075	+1.833	<.001	<.001	3	9
BLOOD_Myeloma	Respiratory electron transport chain →	+0.089	+1.833	<.001	.001	3	8
BLOOD_Myeloma	Aerobic electron transport chain →	+0.064	+1.318	.002	.003	3	7
BLOOD_Myeloma	Mitochondrial electron transport, NADH to ubiquinone →	+0.101	+1.865	<.001	.001	3	7
UPPER_AERODIGESTIVE_TRACT	Purine nucleoside triphosphate metabolic process →	+0.068	+1.708	.002	<.001	3	7
LUNG_NSCLC_LUAD	Fatty acid catabolic process →	+0.065	+1.512	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,379 associations by consensus.

Electron transport chain by METTL27 expression — BLOOD_Myeloma

Explore this box plot interactively →