METTL27

Across TCGA cell cohorts, METTL27 protein abundance is significantly associated with the go_rna of many other GO terms, with 367 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible METTL27-associated GO terms across cancer lineages are Positive regulation of cardiocyte differentiation, Negative regulation of sodium ion transport, and C-terminal protein amino acid modification. Each is linked with METTL27 in more than 2 cancer types. Because this analysis shows association rather than direction, both METTL27-to-partner and partner-to-METTL27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cardiocyte differentiation grouped by METTL27-low versus METTL27-high in SKIN.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL27→partner) and Y-score (partner→METTL27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Positive regulation of cardiocyte differentiation →	-0.180	-1.946	<.001	<.001	3	3
LUNG_NSCLC_LUAD	Negative regulation of sodium ion transport →	+0.130	+1.563	.005	.004	3	2
LUNG_NSCLC_LUAD	C-terminal protein amino acid modification →	-0.193	-1.760	.004	<.001	3	2
LUNG_NSCLC_LUAD	Regulation of establishment of cell polarity →	-0.084	-1.596	<.001	.001	3	2
STOMACH	Regulation of signal transduction by p53 class mediator →	-0.073	-2.663	.004	.006	3	2
BREAST	Positive regulation of autophagy of mitochondrion →	-0.099	-2.797	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 367 associations by consensus.

Positive regulation of cardiocyte differentiation by METTL27 expression — SKIN

Explore this box plot interactively →