METTL26

Across TCGA cell cohorts, METTL26 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,986 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible METTL26-associated GO terms across cancer lineages are rRNA pseudouridine synthesis, Enzyme-directed rRNA pseudouridine synthesis, and Peptidyl-methionine modification. Each is linked with METTL26 in more than 15 cancer types. Because this analysis shows association rather than direction, both METTL26-to-partner and partner-to-METTL26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA pseudouridine synthesis grouped by METTL26-low versus METTL26-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL26→partner) and Y-score (partner→METTL26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	rRNA pseudouridine synthesis →	+0.113	+0.986	<.001	<.001	3	16
LUNG_SCLC	Enzyme-directed rRNA pseudouridine synthesis →	+0.122	+0.917	<.001	<.001	3	14
LUNG_SCLC	Peptidyl-methionine modification →	+0.199	+0.668	.007	<.001	3	13
URINARY_TRACT	Metanephric proximal tubule development →	+0.221	+0.918	<.001	<.001	2	12
URINARY_TRACT	Response to methylglyoxal →	+0.154	+1.080	<.001	<.001	3	10
BONE	Cytoplasm protein quality control by the ubiquitin-proteasome system →	+0.163	+0.665	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,986 associations by consensus.

rRNA pseudouridine synthesis by METTL26 expression — LUNG_SCLC

Explore this box plot interactively →