METTL25

Across TCGA patient cohorts, METTL25 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL25-associated genes across cancer lineages are ASNS, ATM, and 14-3-3_beta. Each is linked with METTL25 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL25-to-partner and partner-to-METTL25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by METTL25-low versus METTL25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL25→partner) and Y-score (partner→METTL25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.398	+2.115	.011	.019	3	2
UCEC	ATM →	-0.610	-3.321	.002	.010	3	2
UCEC	14-3-3_beta →	-0.099	-3.143	.025	.018	3	1
UCEC	EGFR_pY1068 →	-0.369	-3.906	<.001	<.001	3	1
UCEC	JNK_pT183_Y185 →	-0.203	-2.794	.005	.003	3	1
UCEC	Ku80 →	+0.259	+2.179	.012	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

ASNS by METTL25 expression — UCEC

Explore this box plot interactively →