METTL25

Across TCGA cell cohorts, METTL25 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,435 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible METTL25-associated GO terms across cancer lineages are Chromosomal 5-methylcytosine DNA demethylation pathway, Positive regulation of double-strand break repair, and DNA-templated DNA replication maintenance of fidelity. Each is linked with METTL25 in more than 8 cancer types. Because this analysis shows association rather than direction, both METTL25-to-partner and partner-to-METTL25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chromosomal 5-methylcytosine DNA demethylation pathway grouped by METTL25-low versus METTL25-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL25→partner) and Y-score (partner→METTL25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Chromosomal 5-methylcytosine DNA demethylation pathway →	+0.152	+0.858	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Positive regulation of double-strand break repair →	+0.064	+0.644	.007	.006	3	8
OESOPHAGUS	DNA-templated DNA replication maintenance of fidelity →	+0.098	+0.870	.001	.002	3	8
BREAST	Protein O-linked glycosylation via mannose →	+0.099	+0.870	<.001	<.001	3	7
OESOPHAGUS	Replication fork processing →	+0.111	+0.784	<.001	.004	3	7
LIVER	Golgi to endosome transport →	+0.063	+0.610	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,435 associations by consensus.

Chromosomal 5-methylcytosine DNA demethylation pathway by METTL25 expression — BLOOD_Lymphoma

Explore this box plot interactively →