METTL25

Across TCGA cell cohorts, METTL25 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible METTL25-associated genes across cancer lineages are KRT39, FABP9, and MRGPRX1. Each is linked with METTL25 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL25-to-partner and partner-to-METTL25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT39 grouped by METTL25-low versus METTL25-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL25→partner) and Y-score (partner→METTL25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KRT39 →	+0.052	+3.321	<.001	.006	3	2
URINARY_TRACT	FABP9 →	+0.056	+5.087	<.001	.004	3	1
BLOOD_Leukemia	MRGPRX1 →	+0.051	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR2AP1 →	+0.019	+5.539	<.001	.003	3	1
BLOOD_Leukemia	OR5P3 →	+0.125	+5.201	<.001	.006	3	1
BLOOD_Leukemia	FAM9A →	+0.019	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

KRT39 by METTL25 expression — BLOOD_Lymphoma

Explore this box plot interactively →