METTL23

Across TCGA cell cohorts, METTL23 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,933 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible METTL23-associated GO terms across cancer lineages are Epigenetic programing of male pronucleus, Negative regulation of beige fat cell differentiation, and Positive regulation of hematopoietic stem cell proliferation. Each is linked with METTL23 in more than 10 cancer types. Because this analysis shows association rather than direction, both METTL23-to-partner and partner-to-METTL23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic programing of male pronucleus grouped by METTL23-low versus METTL23-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL23→partner) and Y-score (partner→METTL23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Epigenetic programing of male pronucleus →	+0.144	+0.649	<.001	<.001	3	11
LIVER	Negative regulation of beige fat cell differentiation →	+0.127	+0.556	.006	.006	3	10
UPPER_AERODIGESTIVE_TRACT	Positive regulation of hematopoietic stem cell proliferation →	+0.122	+0.691	<.001	.001	3	9
PANCREAS	Meiotic DNA recombinase assembly →	+0.111	+0.568	.002	<.001	3	8
BLOOD_Lymphoma	Non-motile cilium assembly →	+0.036	+0.502	<.001	<.001	3	7
PANCREAS	Brain morphogenesis →	+0.134	+0.795	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,933 associations by consensus.

Epigenetic programing of male pronucleus by METTL23 expression — SOFT_TISSUE

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