METTL21A

Across TCGA cell cohorts, METTL21A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,932 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible METTL21A-associated GO terms across cancer lineages are Negative regulation of protein folding, Negative regulation of cell adhesion, and 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process. Each is linked with METTL21A in more than 16 cancer types. Because this analysis shows association rather than direction, both METTL21A-to-partner and partner-to-METTL21A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein folding grouped by METTL21A-low versus METTL21A-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL21A→partner) and Y-score (partner→METTL21A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of protein folding →	+0.139	+1.369	.003	<.001	3	17
BONE	Negative regulation of cell adhesion →	-0.097	-0.735	<.001	<.001	3	11
LUNG_NSCLC_LUSC	1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process →	+0.118	+0.972	.005	.003	3	11
BLOOD_Myeloma	DNA replication initiation →	+0.170	+0.738	<.001	<.001	3	11
BLOOD_Lymphoma	Mitotic intra-S DNA damage checkpoint signaling →	+0.117	+1.127	<.001	<.001	3	11
LIVER	Response to steroid hormone →	-0.072	-0.802	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,932 associations by consensus.

Negative regulation of protein folding by METTL21A expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →