METTL1P1

Across TCGA pan-cancer cohorts, METTL1P1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated METTL1P1 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher METTL1P1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated METTL1P1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and ESCA show a favorable association.

MESO, LIHC, and LGG are the cancer types where METTL1P1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.235	0.587	<.001	126	view →
LIHC	OS	Tertile	II,III,IV	0.462	0.733	.005	36	view →
LGG	DFS	Tertile	All	0.256	0.434	<.001	33	view →
BLCA	DFS	Tertile	All	0.685	0.441	.035	30	view →
LUAD	OS	Tertile	All	0.537	0.703	.014	21	view →
TGCT	OS	Tertile	II,III,IV	0.752	1.000	.019	18	view →
KIRC	DFS	Quartile	All	0.425	0.734	.002	13	view →
ESCA	OS	Median	IV	0.698	0.222	.006	12	view →
BRCA	DFS	Tertile	IV	1.000	0.574	.021	10	view →
CHOL	OS	Tertile	All	0.114	0.623	.033	9	view →
UVM	DFS	Tertile	III,IV	0.071	0.636	<.001	9	view →
THCA	OS	Tertile	IV	0.832	1.000	.035	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

METTL1P1–MESO (OS)

Open the MESO breakdown →