METTL18

Across TCGA patient cohorts, METTL18 protein abundance is significantly associated with the RNA expression of many other genes, with 3,754 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible METTL18-associated genes across cancer lineages are RIPK2, UCHL5, and UTP25. Each is linked with METTL18 in more than 2 cancer types. Because this analysis shows association rather than direction, both METTL18-to-partner and partner-to-METTL18 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, METTL18 versus RIPK2 in PDAC, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL18→partner) and Y-score (partner→METTL18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RIPK2 →	+0.503	+0.830	.001	.003	3	3
UCEC	UCHL5 →	+0.559	+0.328	<.001	<.001	3	3
BRCA	UTP25 →	+0.446	+0.273	<.001	<.001	3	3
BRCA	DAP3 →	+0.459	+0.304	<.001	<.001	3	3
LUAD	C1orf112 →	+0.560	+0.237	<.001	<.001	3	3
LSCC	TMEM132D →	+0.345	+0.202	.002	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,754 associations by consensus.

METTL18 vs RIPK2 — PDAC

Explore this scatter interactively →