METTL18

Across TCGA patient cohorts, METTL18 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL18-associated genes across cancer lineages are p21, STAT3_pY705, and Notch1. Each is linked with METTL18 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL18-to-partner and partner-to-METTL18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p21 grouped by METTL18-low versus METTL18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL18→partner) and Y-score (partner→METTL18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p21 →	+0.202	+2.820	.045	.035	3	1
UCEC	STAT3_pY705 →	-0.435	-3.321	.001	.010	3	1
UCEC	Notch1 →	+0.227	+2.817	.002	.036	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

p21 by METTL18 expression — UCEC

Explore this box plot interactively →