METTL18

Across TCGA cell cohorts, METTL18 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible METTL18-associated genes across cancer lineages are OOSP4A and KRT31. Each is linked with METTL18 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL18-to-partner and partner-to-METTL18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OOSP4A grouped by METTL18-low versus METTL18-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL18→partner) and Y-score (partner→METTL18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OOSP4A →	+0.111	+3.793	<.001	.007	3	1
BLOOD_Lymphoma	KRT31 →	+0.069	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

OOSP4A by METTL18 expression — LARGE_INTESTINE

Explore this box plot interactively →