METTL16

Across TCGA patient cohorts, METTL16 mutation is significantly associated with the RNA expression of many other genes, with 2,922 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL16-associated genes across cancer lineages are CXCL1P1, GNAI2P2, and LINC01904. Each is linked with METTL16 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL16-to-partner and partner-to-METTL16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CXCL1P1 grouped by METTL16-low versus METTL16-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL16→partner) and Y-score (partner→METTL16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	CXCL1P1 →	+0.275	+4.421	<.001	.009	3	2
LUAD	GNAI2P2 →	+0.092	+5.376	<.001	.001	3	2
LUAD	LINC01904 →	+0.076	+5.444	<.001	.002	3	2
BRCA	RN7SKP221 →	+0.099	+8.471	<.001	.005	3	2
UCEC	ZNRF1 →	+0.570	+2.828	<.001	<.001	3	2
UCEC	BNIP3P1 →	+0.483	+2.839	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,922 associations by consensus.

CXCL1P1 by METTL16 expression — READ

Explore this box plot interactively →