METTL16

Across TCGA patient cohorts, METTL16 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL16-associated genes across cancer lineages are Di-Ras3, A-Raf_pS299, and FoxM1. Each is linked with METTL16 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL16-to-partner and partner-to-METTL16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by METTL16-low versus METTL16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL16→partner) and Y-score (partner→METTL16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.186	-1.906	.001	.016	3	2
UCEC	A-Raf_pS299 →	-0.162	-3.584	<.001	.002	3	1
UCEC	FoxM1 →	+0.276	+2.331	.008	.019	3	1
UCEC	Gab2 →	+0.375	+1.906	.009	.016	3	1
UCEC	ACVRL1 →	-0.116	-2.446	.035	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.163	-2.459	.016	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Di-Ras3 by METTL16 expression — UCEC

Explore this box plot interactively →