METTL16

Across TCGA cell cohorts, METTL16 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible METTL16-associated genes across cancer lineages are TMEM114, OR11H2, and SPACA1. Each is linked with METTL16 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL16-to-partner and partner-to-METTL16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM114 grouped by METTL16-low versus METTL16-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL16→partner) and Y-score (partner→METTL16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TMEM114 →	+0.065	+4.977	<.001	.007	3	1
BLOOD_Leukemia	OR11H2 →	+0.060	+5.201	<.001	.006	3	1
OVARY	SPACA1 →	+0.023	+5.807	<.001	.001	3	1
OVARY	DPPA5 →	+0.048	+5.196	<.001	.005	3	1
OVARY	GRIFIN →	+0.045	+5.196	<.001	.005	3	1
LARGE_INTESTINE	CHRNA2 →	+0.100	+3.453	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

TMEM114 by METTL16 expression — SKIN

Explore this box plot interactively →