METTL14

Across TCGA pan-cancer cohorts, METTL14 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated METTL14 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher METTL14 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated METTL14 expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

HNSC, LSCC, and COAD are the cancer types where METTL14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.637	0.962	<.001	68	view →
LSCC	DFS	Median	III,IV	0.348	0.868	.004	23	view →
COAD	DFS	Tertile	II,III,IV	1.000	0.840	.035	12	view →
CCRCC	DFS	Tertile	III,IV	1.000	0.299	.033	6	view →
PDAC	DFS	Tertile	III,IV	0.766	0.297	.012	5	view →
LUAD	OS	Median	II,III,IV	0.913	0.331	.001	4	view →
UCEC	DFS	Tertile	All	0.940	0.786	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

METTL14–HNSC (DFS)

Open the HNSC breakdown →