METTL14

Across TCGA pan-cancer cohorts, METTL14 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of METTL14’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where METTL14 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types METTL14 is over-expressed in tumor, although a few such as PDAC and COAD show the opposite, repressed pattern.

LUAD, PDAC, and COAD are the cancer types where METTL14 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in METTL14 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	+0.260	<.001	8	view →
PDAC	Male	II,III,IV	−0.264	.001	4	view →
COAD	All	All	−0.212	.002	4	view →
LSCC	Male	All	+0.107	<.001	4	view →
CCRCC	All	IV	−0.176	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

METTL14–LUAD

Open the LUAD breakdown →