METTL14

Across TCGA patient cohorts, METTL14 protein abundance is significantly associated with the RNA expression of many other genes, with 10,741 significant associations in total. GBM shows the largest number of these associations.

The most reproducible METTL14-associated genes across cancer lineages are TTC5, DMAC2L, and PPP1R3E. Each is linked with METTL14 in more than 5 cancer types. Because this analysis shows association rather than direction, both METTL14-to-partner and partner-to-METTL14 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, METTL14 versus TTC5 in LSCC, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL14→partner) and Y-score (partner→METTL14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TTC5 →	+0.653	+0.323	<.001	<.001	3	6
GBM	DMAC2L →	+0.538	+0.344	<.001	<.001	3	6
GBM	PPP1R3E →	+0.509	+0.249	<.001	<.001	3	6
UCEC	C14orf93 →	+0.419	+0.184	<.001	.009	3	5
OV	CCNB1IP1 →	+0.773	+0.251	<.001	.003	3	5
OV	APEX1 →	+0.523	+0.230	<.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,741 associations by consensus.

METTL14 vs TTC5 — LSCC

Explore this scatter interactively →