METTL14

Across TCGA patient cohorts, METTL14 mutation is significantly associated with the RNA expression of many other genes, with 580 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL14-associated genes across cancer lineages are ARL2BPP1, TRAJ57, and TRAJ21. Each is linked with METTL14 in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL14-to-partner and partner-to-METTL14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARL2BPP1 grouped by METTL14-low versus METTL14-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL14→partner) and Y-score (partner→METTL14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	ARL2BPP1 →	+0.117	+4.497	<.001	.009	3	2
UCEC	TRAJ57 →	+0.396	+1.997	<.001	.007	3	2
SKCM	TRAJ21 →	+0.657	+3.661	<.001	.009	3	2
SKCM	MIR516A1 →	+0.425	+4.385	<.001	.008	3	2
BLCA	MIR301B →	+0.534	+5.814	<.001	.001	3	2
UCEC	SRGAP2D →	-0.244	-2.520	.006	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 580 associations by consensus.

ARL2BPP1 by METTL14 expression — BLCA

Explore this box plot interactively →