METTL14

Across TCGA cell cohorts, METTL14 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,579 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible METTL14-associated GO terms across cancer lineages are Forebrain radial glial cell differentiation, Regulation of hematopoietic progenitor cell differentiation, and Protein neddylation. Each is linked with METTL14 in more than 17 cancer types. Because this analysis shows association rather than direction, both METTL14-to-partner and partner-to-METTL14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Forebrain radial glial cell differentiation grouped by METTL14-low versus METTL14-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL14→partner) and Y-score (partner→METTL14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Forebrain radial glial cell differentiation →	+0.180	+0.692	<.001	.002	3	18
BLOOD_Myeloma	Regulation of hematopoietic progenitor cell differentiation →	+0.111	+0.847	<.001	.002	2	15
BREAST	Protein neddylation →	+0.110	+0.792	<.001	.001	3	14
LUNG_SCLC	Radial glial cell differentiation →	+0.153	+0.719	.001	.001	3	14
STOMACH	Negative regulation of transcription by RNA polymerase I →	+0.129	+0.518	<.001	<.001	3	13
LARGE_INTESTINE	DNA alkylation repair →	+0.121	+0.757	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,579 associations by consensus.

Forebrain radial glial cell differentiation by METTL14 expression — SOFT_TISSUE

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