METTL14-DT

Across TCGA pan-cancer cohorts, METTL14-DT RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated METTL14-DT data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher METTL14-DT RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated METTL14-DT expression acts as an unfavorable survival marker, although some lineages such as BRCA and BLCA show a favorable association.

KICH, KIRC, and BRCA are the cancer types where METTL14-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.682	1.000	.007	55	view →
KIRC	DFS	Median	IV	0.205	0.497	.001	32	view →
BRCA	OS	Median	III,IV	0.960	0.842	<.001	32	view →
GBM	DFS	Tertile	All	0.172	0.417	.002	29	view →
BLCA	DFS	Tertile	All	0.432	0.273	.003	28	view →
LGG	OS	Tertile	All	0.607	0.367	<.001	26	view →
ACC	DFS	Median	IV	0.594	0.151	.003	25	view →
UCS	DFS	Tertile	IV	0.936	0.399	.017	24	view →
READ	OS	Median	III,IV	0.682	0.308	.003	22	view →
PAAD	DFS	Median	II,III,IV	0.473	0.265	.007	19	view →
CHOL	DFS	Median	III,IV	0.647	0.127	.006	18	view →
PRAD	DFS	Median	All	0.901	0.963	.003	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

METTL14-DT–KICH (DFS)

Open the KICH breakdown →