Across TCGA patient cohorts, METTL11B mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible METTL11B-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and FOXO3a_pS318_S321. Each is linked with METTL11B in more than 1 cancer types. Because this analysis shows association rather than direction, both METTL11B-to-partner and partner-to-METTL11B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (METTL11B→partner) and Y-score (partner→METTL11B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.346	-3.321	.003	.010	3	1
UCEC	A-Raf_pS299 →	-0.226	-3.169	<.001	.018	3	1
UCEC	FOXO3a_pS318_S321 →	-0.170	-2.312	.003	.034	3	1
UCEC	GAPDH →	+0.493	+3.000	.049	.036	3	1
UCEC	Ku80 →	+0.245	+1.887	.025	.031	3	1
UCEC	MAPK_pT202_Y204 →	-0.446	-3.000	.041	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

METTL11B survival (RNA) · tumor vs normal (RNA) · all METTL11B data types